Increased risk of preterm birth among women with mitral valve prolapse: a nationwide, population-based study.

Abstract

PURPOSE:

Using nationwide population-based databases, we aimed to assess the association between mitral valve prolapse (MVP) and adverse pregnancy outcomes.

METHODS:

The Taiwan Birth Registry and the National Health Insurance Research Dataset were used for analysis. Of all pregnant women in Taiwan who had singleton births in 2005, we identified a total of 3104 mothers diagnosed with MVP during ambulatory or emergency care visits, together with 12,245 mothers unaffected by MPV. Multivariate logistic regression was performed.

RESULTS:

Multivariate logistic regressions showed that, compared with unaffected mothers, the adjusted odds ratios of preterm birth and cesarean section for mothers with MVP were 1.27 (95% confidence interval [CI], 1.10-1.48) and 1.34 (95% CI, 1.20-1.50), respectively. In further stratification based on the timing of the MVP diagnosis, the highest risks of preterm birth were observed for mothers diagnosed with MVP during (but not before) pregnancy (odds ratio [OR], 1.54; p = .001). No significant difference was observed between women with and without MVP for other outcomes such as low birthweight, intrapartum complications, low Apgar scores, and congenital malformations.

CONCLUSIONS:

Our study found a significant risk of preterm delivery among women with MVP. A multidisciplinary team approach to providing obstetric care, with the mission of monitoring signs of cardiac complications and preterm birth, is imperative.

• Authors: Chao-Hung Chen, Ming-Chao Huang, Hung-Chang Liu, Chang-Jer Huang, Herng-Ching Lin, Yu Ru Kou
• Journal: Annals of epidemiology (Ann Epidemiol) Vol. 21 Issue 6 Pg. 391-8 (Jun 2011) ISSN: 1873-2585 [Electronic] United States
• PMID: 21435902 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Confidence Intervals
• Female
• Humans
• Male
• Mitral Valve Prolapse (epidemiology)
• Multivariate Analysis
• Odds Ratio
• Pregnancy
• Pregnancy Complications
• Pregnancy Outcome
• Premature Birth (epidemiology, etiology)
• Registries
• Risk Assessment
• Taiwan (epidemiology)
• Young Adult