[Infiltrating ductal breast carcinoma after radiotherapy and chemotherapy for non-Hodgkin's lymphoma in a young woman. Case report].

Abstract

Lymphoma was one of the first cancers curable by radiotherapy and/or chemotherapy. However the increased risk of second malignancies in lymphoma survivors appeared to be the price of success of modern treatment modalities. In particular, breast cancer has been a major concern among women irradiated for lymphoma at a young age. There are several reports of breast cancer after Hodgkin's lymphoma, but few after non-Hodgkin's lymphoma. Owing to the particularity of this condition and the difficulties in its diagnosis and treatment, we wish to report the case of ductal infiltrant carcinoma of the breast in a young woman survived to a non-Hodgkin's lymphoma. Women who are survivors of pediatric lymphoma have a significantly increased risk of subsequent breast cancer compared with the general population and are at a high risk of developing bilateral disease within a short interval. Several studies have shown that the relative risk for secondary breast cancer becomes significantly increased between 5 and 9 years and rises dramatically between 15 and 19 years after lymphoma treatment. Screening programs to detect breast cancer should be initiated early after Hodgkin's and non-Hodgkin's lymphomas. Screening have to include breast self examinations every month, clinical breast examinations every 6 months, and mammography every 2-3 years. The patients should start breast self-examination at puberty. In these high-risk patients, "aggressive" biopsy is appropriate for suspicious lesions.

• Authors: M G Onesti, M Mazzocchi, S Di Ronza, A Martano, N Scuderi
• Journal: Il Giornale di chirurgia (G Chir) 2011 Jan-Feb Vol. 32 Issue 1-2 Pg. 37-40 ISSN: 0391-9005 [Print] Italy
• Vernacular Title: Carcinoma duttale infiltrante della mammella dopo radioterapia e chemioterapia per linfoma non Hodgkin in una giovane donna. Case report.
• PMID: 21352706 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Breast Neoplasms (etiology)
• Carcinoma, Ductal, Breast (etiology)
• Female
• Humans
• Lymphoma, Non-Hodgkin (complications, drug therapy, radiotherapy, therapy)
• Neoplasms, Radiation-Induced (etiology)
• Neoplasms, Second Primary (etiology)