A two-locus system controls susceptibility to colitis-associated colon cancer in mice.
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| Abstract |
We have previously shown that the differential susceptibility of A/J (susceptible) and C57BL/6J (B6, resistant) mouse strains to azoxymethane (AOM)-induced colorectal cancer (CRC) is controlled by the chromosome 3 locus, Ccs3. We report that A/J and B6 mice also show differential susceptibility to colitis-associated colorectal cancer (CA-CRC) induced by combined administration of AOM and dextran sulfate. This differential susceptibility is not controlled by Ccs3, but is under distinct genetic control. Linkage analyses in (A/J x B6)F2 mice detected a major CA-CRC susceptibility locus on chromosome 9 (Ccs4) which controls tumor multiplicity and tumor surface area. Susceptibility alleles at Ccs4 are inherited in a recessive fashion, with A/J alleles being associated with susceptibility. We also detected a second locus on chromosome 14 that acts in an additive fashion with Ccs4. Strikingly, F2 mice homozygous for A/J alleles at both loci (Ccs4 and chromosome 14) are as susceptible to CA-CRC as the A/J controls while mice homozygous for B6 alleles are as resistant as the B6 controls, thus supporting the role of two interacting loci in this CA-CRC model. This indicates that susceptibility to chemically-induced CRC and susceptibility to CA-CRC are under distinct genetic control in mice, and probably involve distinct cellular pathways.
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| Authors | Lauren Van Der Kraak, Charles Meunier, Claire Turbide, Serge Jothy, Louis Gaboury, Victoria Marcus, Sing Yun Chang, Nicole Beauchemin, Philippe Gros |
| Journal | Oncotarget (Oncotarget) Vol. 1 Issue 6 Pg. 436-46 (Oct 2010) ISSN: 1949-2553 [Electronic] United States |
| PMID | 21311099 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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