Langerhans cell histiocytosis treated with narrow-band ultraviolet B.

Abstract

A 58-year-old man had widespread multiple erythemas that had been untreated for 20 years. The cutaneous lesions increased in size for a year. Histopathological examination revealed increased number of large, dysplastic, histiocytic cells in the dermis; most of these cells tested positive for Langelin, CD1a and S-100 staining. The patient was diagnosed with Langerhans cell histiocytosis (LCH) and treated with narrow-band ultraviolet B (NB-UVB) radiation. The erythema improved after treatment, but the tumor remained. Therefore, the tumor was surgically excised. NB-UVB therapy might be effective for the treatment of superficial lesions, but not tumoral lesions of LCH.

• Authors: Michiko Aihara, Toshio Hasegawa, Yasuhiro Okuyama, Masataro Hiruma, Shigaku Ikeda
• Journal: The Journal of dermatology (J Dermatol) Vol. 38 Issue 2 Pg. 151-4 (Feb 2011) ISSN: 1346-8138 [Electronic] England
• PMID: 21269310 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2010 Japanese Dermatological Association.

Topics

• Histiocytosis, Langerhans-Cell (pathology, radiotherapy)
• Humans
• Male
• Middle Aged
• Skin Diseases (pathology, radiotherapy)
• Treatment Outcome
• Ultraviolet Rays
• Ultraviolet Therapy