The thyrotropin releasing hormone analogue, RGH 2202, reverses experimental haemorrhagic shock in rats.

Abstract

Hypovolemic shock was produced in rats by withdrawing about 50% of the estimated total blood volume. Following mean arterial pressure stabilization in the range of 22-23 mm Hg, the rats were given an i.v. bolus injection of L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline amide (RGH-2202) to be compared with thyrotropin-releasing hormone (TRH). RGH-2202, administered within 5 min following shock induction, dose dependently improved the mean arterial pressure and survival of the rats. The activity of RGH-2202 was superior to that of TRH after i.v. administration; both drugs showed a lower activity after i.m. administration.

• Authors: G Coppi, A Falcone
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 182 Issue 1 Pg. 185-8 (Jun 21 1990) ISSN: 0014-2999 [Print] Netherlands
• PMID: 2119310 (Publication Type: Journal Article)

Chemical References

• Thyrotropin-Releasing Hormone
• posatirelin

Topics

• Animals
• Blood Pressure (drug effects)
• Dose-Response Relationship, Drug
• Female
• Rats
• Rats, Inbred Strains
• Shock, Hemorrhagic (drug therapy)
• Thyrotropin-Releasing Hormone (analogs & derivatives, therapeutic use)