Comparable outcomes in donation after cardiac death and donation after brainstem death: a matched analysis of renal transplants.

Abstract

Donation after cardiac death (DCD) donors provide a valuable source of grafts for renal transplantation. They are exposed to an initial warm ischemic insult, which can affect early function. We sought to compare our initial DCD experience in renal transplantation with a case-matched donation after brain death (DBD) cohort from the same period. We included all DCD transplantations in the first 5 years of the program. A control DBD group was matched with a variety of donor and recipient factors. We demonstrated a significantly increased early dysfunction (DGF and primary nonfunction). DCD graft function was poorer than the DBD equivalent at 1- and 3-years. However, medium-term recipient and graft outcomes were comparable. DCD grafts continue to play a vital role in renal transplantation despite evidence of early graft dysfunction.

• Authors: J K Pine, P J Goldsmith, D M Ridgway, A J Cockbain, S Farid, S Fraser, S G Pollard, M Attia, K V Menon, N Ahmad
• Journal: Transplantation proceedings (Transplant Proc) Vol. 42 Issue 10 Pg. 3947-8 (Dec 2010) ISSN: 1873-2623 [Electronic] United States
• PMID: 21168594 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Topics

• Brain Death
• Brain Stem (physiopathology)
• Cohort Studies
• Death
• Female
• Humans
• Kidney Transplantation
• Male
• Middle Aged
• Tissue Donors
• Tissue and Organ Procurement