Abstract | BACKGROUND/PURPOSE: METHODS: Three hundred and forty-one patients who underwent hepatectomy for ICC between 1995 and 2004 at the 9 institutions of the Medical University Hospitals were analyzed retrospectively. Multivariate regression analyses and a Kaplan-Meyer analysis were performed to identify prognostic factors. RESULTS: Pathological lymph node metastasis was one of the significant factors affecting overall survival (hazard ratio 2.10, p < 0.001) based on the multivariate analysis. Among the patients who underwent extended lymphadenectomy beyond the hepatoduodenal ligament, the median survival of 121 patients with nodal involvement was 12.2 months. Only seven patients with nodal involvement have survived for more than 4 years. CONCLUSIONS: In the present study, preoperative carbohydrate antigen (CA) 19-9, intrahepatic metastasis, and nodal involvement were the significant independent predictors of poor prognosis by multivariate analysis. Further prospective studies may thus be needed to confirm these findings, because this study has a limitation in that it was a retrospective study with multicenter data collection.
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Authors | Kazuhisa Uchiyama, Masakazu Yamamoto, Hiroki Yamaue, Shun-ichi Ariizumi, Taku Aoki, Norihiro Kokudo, Tomoki Ebata, Masato Nagino, Masayuki Ohtsuka, Masaru Miyazaki, Eiichi Tanaka, Satoshi Kondo, Takahiro Uenishi, Shoji Kubo, Hiroshi Yoshida, Michiaki Unno, Satoru Imura, Mitsuo Shimada, Masaki Ueno, Tadahiro Takada |
Journal | Journal of hepato-biliary-pancreatic sciences
(J Hepatobiliary Pancreat Sci)
Vol. 18
Issue 3
Pg. 443-52
(May 2011)
ISSN: 1868-6982 [Electronic] Japan |
PMID | 21132443
(Publication Type: Comparative Study, Journal Article, Multicenter Study)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bile Duct Neoplasms
(epidemiology, pathology, surgery)
- Bile Ducts, Intrahepatic
- Cholangiocarcinoma
(epidemiology, secondary, surgery)
- Female
- Follow-Up Studies
- Hepatectomy
(methods)
- Humans
- Incidence
- Japan
(epidemiology)
- Liver Neoplasms
(epidemiology, secondary, surgery)
- Lymphatic Metastasis
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Societies, Medical
- Survival Rate
(trends)
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