Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.

Abstract

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.

• Authors: M Matsuoka, K-T Jeang
• Journal: Oncogene (Oncogene) Vol. 30 Issue 12 Pg. 1379-89 (Mar 24 2011) ISSN: 1476-5594 [Electronic] England
• PMID: 21119600 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Basic-Leucine Zipper Transcription Factors
• HBZ protein, human T-cell leukemia virus type I
• Retroviridae Proteins
• Viral Proteins

Topics

• Basic-Leucine Zipper Transcription Factors (genetics, metabolism)
• Cell Transformation, Viral
• DNA Damage
• DNA Repair
• Genes, pX
• Human T-lymphotropic virus 1 (genetics, metabolism, pathogenicity)
• Humans
• Leukemia-Lymphoma, Adult T-Cell (drug therapy, immunology, virology)
• Retroviridae Proteins
• Viral Proteins (genetics, metabolism)