Age and preoperative total bilirubin level can stratify prognosis after extracorporeal pulsatile left ventricular assist device implantation.

Abstract

BACKGROUND:

In Japan, the TOYOBO left ventricular assist device (LVAD) has been commercially available for heart failure patients as of 2010, but clinical risk stratification before implantation has not been widely performed.

METHODS AND RESULTS:

In the present study data from 47 patients (age 38.6 ± 14.6 [SD] years, male 74.5%, non-ischemic 74.5%) implanted with a TOYOBO LVAD between November 2002 and February 2010 were analyzed. Kaplan-Meier survival analysis showed significantly higher mortality in the patients who had cardiogenic shock preoperatively (P = 0.031). Multivariate analysis revealed that the preoperative total bilirubin level (odds ratio [OR] 1.312, P < 0.001) and age (OR 1.076, P = 0.013) were independent risk factors for death. Perioperative necessity of a right ventricular assist device was also an independent risk factor for poor prognosis.

CONCLUSIONS:

LVAD implantation is preferable before the patient experiences hemodynamic collapse. The preoperative total bilirubin level can be used to predict prognosis after device implantation in end-stage heart failure patients.

• Authors: Taro Shiga, Koichiro Kinugawa, Masaru Hatano, Atsushi Yao, Takashi Nishimura, Miyoko Endo, Naoko Kato, Yasunobu Hirata, Shunei Kyo, Minoru Ono, Ryozo Nagai
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 75 Issue 1 Pg. 121-8 ( 2011) ISSN: 1347-4820 [Electronic] Japan
• PMID: 21116070 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Bilirubin

Topics

• Adult
• Age Factors
• Bilirubin (blood)
• Biomarkers (blood)
• Chi-Square Distribution
• Female
• Heart Failure (blood, mortality, physiopathology, therapy)
• Heart-Assist Devices (adverse effects)
• Hemodynamics
• Humans
• Japan
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Odds Ratio
• Predictive Value of Tests
• Proportional Hazards Models
• Prosthesis Design
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Shock, Cardiogenic (blood, physiopathology, therapy)
• Time Factors
• Treatment Outcome
• Ventricular Function, Left
• Young Adult