Primary gingival angiosarcoma successfully treated by radiotherapy with concurrent intra-arterial chemotherapy.

Abstract

The occurrence of angiosarcoma in the oral cavity is extremely rare, and optimal management of this tumor is undefined. These tumors are aggressive, with a high propensity for local recurrence. We present here a case of primary gingival angiosarcoma successfully treated by intra-arterial chemotherapy concurrent with radiation therapy. A 69-year-old female with a primary angiosarcoma in the right maxillary gingiva was admitted to our hospital. The diagnosis of angiosarcoma was established by immunohistochemistry. The patient refused surgical treatment, and so intra-arterial cisplatin and concurrent radiation were given. The gingival tumor disappeared after completion of the therapeutic regimen. However, the patient died 8 months after initial treatment because of multiple lung metastases. Locoregional control was achieved up to her death. To our knowledge, this is the first report of this treatment for angiosarcoma of the oral cavity.

• Authors: Gen Suzuki, Etsuyo Ogo, Ryuichiro Tanoue, Norimitsu Tanaka, Yuko Watanabe, Toshi Abe, Osamu Iwamoto, Jingo Kusukawa, Naofumi Hayabuchi
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 16 Issue 4 Pg. 439-43 (Aug 2011) ISSN: 1437-7772 [Electronic] Japan
• PMID: 21107878 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cisplatin

Topics

• Aged
• Cisplatin (therapeutic use)
• Combined Modality Therapy
• Female
• Gingival Neoplasms (drug therapy, radiotherapy, therapy)
• Hemangiosarcoma (drug therapy, radiotherapy, therapy)
• Humans
• Infusions, Intra-Arterial