Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian.

Abstract

Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the intestinal absorption of forsythoside A were investigated. The observations from in situ intestinal circulation model showed that A/%(h(-1)) of forsythoside A in FF+LSF, FF+SR and SHL were all reduced greatly compared with that in FF. However, in pharmacokinetics study, C(max) and AUC(0→1440) of forsythoside A all increased and T(1/2) prolonged in SHL, FF+LJF and FF+SR compared with FF. The results indicated that the different compositions of SHL decreased absorption but increased bioavailability of forsythoside A, which may be related to its metabolism inhibited in intestine or liver.

• Authors: Wei Zhou, Liu-qing Di, Jin-jun Shan, Xiao-lin Bi, Le-tian Chen, Ling-chong Wang
• Journal: Fitoterapia (Fitoterapia) Vol. 82 Issue 3 Pg. 375-82 (Apr 2011) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 21075181 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Drugs, Chinese Herbal
• Glycosides
• shuang-huang-lian
• forsythiaside

Topics

• Area Under Curve
• Biological Availability
• Chromatography, High Pressure Liquid
• Drugs, Chinese Herbal (chemistry)
• Forsythia
• Fruit
• Glycosides (pharmacokinetics)
• Intestinal Absorption
• Lonicera
• Scutellaria baicalensis