Pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from Panax notoginseng, in healthy volunteers and patients with advanced solid tumors.
Abstract | AIM: METHODS: RESULTS: After a single intravenous dose of 70, 100, or 140 mg·m⁻² was administered to subjects, panaxatrol disuccinate sodium distributed broadly, and the plasma concentration of panaxatrol disuccinate sodium declined rapidly. No significant differences were observed in the main pharmacokinetic parameters among the three dosing groups, including AUC(0-t), MRT(0-t), VRT(0-t), t(1/2Z), CL(z/F), V(z/F), and C₀ (P>0.05). In the multiple-dose pharmacokinetic study, the mean steady-state peak concentration (C(max)), trough concentration (C(min)), average concentration (C(av)), mean steady state AUC (AUC(ss)) and the degree of fluctuation were 13.96±15.48 mg·L⁻¹, 0.18±0.29 mg·L⁻¹, 0.15±0.29 mg·L⁻¹, 3.58±6.94 mg·L⁻¹·h, and 148.00±117.18, respectively. At any given dose of panaxatrol disuccinate sodium, interindividual variability in the pharmacokinetic parameters was obvious. CONCLUSION:
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Authors | Zhao Yan, Zhong-ling Zhu, Hua-qing Wang, Wei Li, Ya-xian Mi, Chang-xiao Liu |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 31
Issue 11
Pg. 1515-22
(Nov 2010)
ISSN: 1745-7254 [Electronic] United States |
PMID | 21052087
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Triterpenes
- panaxatrol disuccinate
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Agents, Phytogenic
(blood, isolation & purification, pharmacokinetics, therapeutic use)
- Chromatography, Liquid
- Dose-Response Relationship, Drug
- Female
- Humans
- Injections, Intravenous
- Male
- Mass Spectrometry
- Middle Aged
- Neoplasms
(blood, drug therapy, metabolism, pathology)
- Panax notoginseng
(chemistry)
- Reproducibility of Results
- Time Factors
- Tissue Distribution
- Triterpenes
(blood, isolation & purification, pharmacokinetics, therapeutic use)
- Young Adult
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