Calpain 10 gene and laryngeal cancer: a survival analysis.

Abstract

BACKGROUND:

Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+-dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 (CAPN10) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of CAPN10 alleles to laryngeal cancer survival.

METHODS:

Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed CAPN10 UCSNP-44, UCSNP-43, UCSNP-19, and UCSNP-63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model.

RESULTS:

UCSNP-19, UCSNP-43, and UCSNP-44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP-63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21-6.20).

CONCLUSION:

CAPN10 UCSNP-63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer.

• Authors: Ramón Moreno-Luna, Antonio Abrante, Francisco Esteban, Miguel Angel González-Moles, Miguel Delgado-Rodríguez, María Eugenia Sáez, Antonio González-Pérez, Reposo Ramírez-Lorca, Luis Miguel Real, Agustín Ruiz
• Journal: Head & neck (Head Neck) Vol. 33 Issue 1 Pg. 72-6 (Jan 2011) ISSN: 1097-0347 [Electronic] United States
• PMID: 20848425 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2010 Wiley Periodicals, Inc. Head Neck, 2011.

Chemical References

• DNA, Neoplasm
• Calpain
• calpain 10

Topics

• Aged
• Alleles
• Analysis of Variance
• Calpain (genetics)
• Cause of Death
• Cohort Studies
• Confidence Intervals
• DNA, Neoplasm (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Genetic Predisposition to Disease
• Humans
• Kaplan-Meier Estimate
• Laryngeal Neoplasms (genetics, mortality, therapy)
• Male
• Middle Aged
• Multivariate Analysis
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide
• Prognosis
• Proportional Hazards Models
• Spain
• Survival Analysis