Predonation quality of life and early postdonation safety of older living renal donors in China.

Abstract

BACKGROUND:

Studies on the safety of older living renal donors are lacking in China.

METHODS:

We observed 142 consecutive living renal donors before and early after (7 days) the operation. There were no prisoners used as donors or recipients. Subjects were divided into 2 groups: older than 50 years of age (n = 40) or younger age (n = 102). We compared differences in early safety between the 2 groups.

RESULTS:

There were no significant differences in 8 aspects of the predonation quality of life using the SF-36 questionnaire, except for physical function (P < .001). Zero hour biopsies performed on 52 kidneys showed 15 to display abnormal renal tissues (28.85%), which was significantly greater among the older age group (P = .034). The perioperative indexes were similar between the 2 groups; however, the hospital stay was longer in the older group (P = .034). Compared with the younger group, the older group generally showed a lower creatinine clearance (CCr; P < .001), higher cystatin c (P = .006), and similar serum creatinine (Scr) preoperatively, conditions that persisted at 7 days postoperatively. Although the increased Scr and reduced CCr were present in all donors, the changes in Scr and CCr were similar between the 2 groups. Differences in urinary micro-albumin and proteinuria before and after operation were not significantly different for both groups.

CONCLUSIONS:

Increased use of older living kidney donors in China may be a safe strategy to meet the demand for transplantation. However, long-term outcomes need further follow-up.

• Authors: L Zhang, J Qiu, L Chen, J Fei, C Wang, S Deng, J Li, G Chen, G Huang
• Journal: Transplantation proceedings (Transplant Proc) Vol. 42 Issue 7 Pg. 2417-21 (Sep 2010) ISSN: 1873-2623 [Electronic] United States
• PMID: 20832518 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2010 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Albuminuria (epidemiology, etiology)
• Blood Pressure (physiology)
• Body Mass Index
• China
• Family
• Humans
• Living Donors (psychology)
• Middle Aged
• Nephrectomy (methods, psychology)
• Perioperative Period (psychology)
• Proteinuria (epidemiology, etiology)
• Quality of Life
• Safety