Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects.

Abstract

Published data on the association between mitogen-activated protein kinase kinase kinase 1 (MAP3K1) gene rs889312 polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of seven eligible articles including 26,015 cases and 33,962 controls based on the search criteria were involved in this meta-analysis. We observed that the MAP3K1 rs889312 polymorphism was significantly correlated with breast cancer risk from the fixed effects model when all studies were pooled into the meta-analysis (the allele contrast model: OR 1.09, 95% CI 1.07-1.12; the homozygote codominant: OR 1.22, 95% CI 1.15-1.29; the heterozygote codominant: OR 1.07, 95% CI 1.04-1.11; the dominant model: OR 1.10, 95% CI 1.06-1.13; the recessive model: OR 1.18, 95% CI 1.12-1.25). No significant association was found in the BRCA1 mutation carriers in all genetic models. When stratified by BRCA2 mutation carriers status, statistically significantly elevated risk was found in this meta-analysis (C vs. A: OR 1.12, 95% CI 1.01-1.23; CC vs. AA: OR 1.35, 95% CI 1.06-1.71; the recessive model: OR 1.31, 95% CI 1.05-1.65). There was no evidence for significant association between MAP3K1 rs889312 polymorphism and breast cancer risk in BRCA1 and BRCA2 positive cohort for all comparison models. In conclusion, this meta-analysis suggests that the MAP3K1 rs889312 C allele is a low-penetrant risk factor for developing breast cancer, and there is limited evidence to indicate that MAP3K1 rs889312 polymorphism is associated with increased risk of breast cancer in BRCA1 mutation carriers.

• Authors: Pei-Hua Lu, Jie Yang, Chen Li, Mu-Xin Wei, Wei Shen, Li-ping Shi, Zhi-Yang Jiang, Ning Zhou, Guo-Qing Tao
• Journal: Breast cancer research and treatment (Breast Cancer Res Treat) Vol. 126 Issue 3 Pg. 663-70 (Apr 2011) ISSN: 1573-7217 [Electronic] Netherlands
• PMID: 20809358 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• MAP Kinase Kinase Kinase 1

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Alleles
• Breast Neoplasms (enzymology, genetics)
• Cohort Studies
• DNA Mutational Analysis
• Female
• Genes, BRCA1
• Genetic Predisposition to Disease
• Heterozygote
• Homozygote
• Humans
• MAP Kinase Kinase Kinase 1 (genetics)
• Middle Aged
• Models, Statistical
• Odds Ratio
• Polymorphism, Genetic
• Prognosis
• Risk
• Sensitivity and Specificity