A collaborative study of cancer incidence and mortality among vinyl chloride workers.

Abstract

A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).

• Authors: L Simonato, K A L'Abbé, A Andersen, S Belli, P Comba, G Engholm, G Ferro, L Hagmar, S Langård, I Lundberg
• Journal: Scandinavian journal of work, environment & health (Scand J Work Environ Health) Vol. 17 Issue 3 Pg. 159-69 (Jun 1991) ISSN: 0355-3140 [Print] Finland
• PMID: 2068554 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Vinyl Chloride

Topics

• Adult
• Brain Neoplasms (chemically induced, epidemiology)
• Cause of Death
• Cohort Studies
• Hemangiosarcoma (chemically induced, epidemiology, mortality)
• Humans
• Liver Neoplasms (chemically induced, epidemiology, mortality)
• Lymphoma (chemically induced, epidemiology)
• Middle Aged
• Occupational Diseases (chemically induced, epidemiology)
• Regression Analysis
• Risk Factors
• Vinyl Chloride (adverse effects)