[Relationship of tumor necrosis factor gene polymorphism and acute graft-versus-host disease after unrelated allogeneic hematopoietic stem cell transplantation].

Abstract

OBJECTIVE:

To explore the relationship between tumor necrosis factor (TNF) gene polymorphisms in donors and recipients and the incidence and severity of acute graft-versus-host diseases (aGVHD) after unrelated allogeneic hematopoietic stem cell transplantation (allo-HSCT).

METHODS:

Single nucleotide polymorphisms (SNPs) of TNFalpha-238 (G/A), TNFalpha-857 (C/T), TNFalpha-863 (C/A), TNFalpha-1031 (T/C), TNFbeta + 252(A/G) were analyzed by Multiplex SNaPshot analysis in 76 pairs of donors and recipients.

RESULTS:

Transplantation involving donors with TNFalpha-857 CC genotype resulted in a higher incidence of grade II-IV aGVHD than donors with CT genotype (91.3% vs 8.7%, P = 0.039). In the 23 patients with grade II-IV aGVHD, no patients had TNFbeta + 252 AA genotype, 19 (82.6%) had GA genotype and 4 (17.4%) had GG genotype. There was a significant difference in the distribution pattern of the TNFbeta + 252 (AA, GA and GG) genotypes in these patients (P = 0.03). There was no significant association of TNFalpha-238 (G/A), TNFalpha-863 (C/A) and TNFalpha-1031(T/C) polymorphisms with the risk of aGVHD.

CONCLUSION:

These results suggest donor TNFalpha-857 CC genotype is related to a higher incidence of grade II-IV aGVHD, and patients with TNFbeta + 252 AA genotype have protection against the risk of grade II-IV aGVHD.

• Authors: Lai Jin, Hao-wen Xiao, Xiao-yu Lai, Gong-qiang Wu, Yi Luo, Ji-min Shi, Ya-min Tan, He Huang
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 49 Issue 4 Pg. 320-4 (Apr 2010) ISSN: 0578-1426 [Print] China
• PMID: 20627040 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lymphotoxin-alpha
• Tumor Necrosis Factor-alpha

Topics

• Adolescent
• Adult
• Child
• Female
• Genotype
• Graft vs Host Disease (genetics)
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Lymphotoxin-alpha (genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Tissue Donors
• Transplantation, Homologous
• Tumor Necrosis Factor-alpha (genetics)
• Young Adult