Abstract | BACKGROUND: METHODS: Patients receiving an LVAD were prospectively recorded. Laboratory and clinical data were extracted and used to calculate the predicted survival with medical therapy using the Seattle Heart Failure Model (SHFM). This was compared with observed survival, hospital length of stay and timeliness of discharge. RESULTS: We identified 104 patients. Survival with an LVAD vs SHFM predicted survival was 69% vs 11% at 1 year, corresponding to a hazard ratio of 0.17 (p < 0.0001). SHFM-estimated 1-year survival with medical therapy increased from 4% in 1997 to 2004 to 25% in 2007-2008 (p < 0.0001). Subgroup analysis of higher vs lower risk LVAD patients showed observed 1-year survival of 83% vs 57% (p = 0.04). The lower risk group had a shorter length of stay (46 vs 75 days, p = 0.03), along with higher rates of discharge prior to transplant (88% vs 61%, p = 0.01) and discharge within 60 days of LVAD placement (77% vs 52%, p = 0.03). CONCLUSIONS: The SHFM allows prediction of important features of a patient's hospital course post-operatively, including length of stay and 1-year survival. Given evidence of improved survival and shorter hospital stay in lower risk patients, earlier LVAD placement based on a prediction model like the SHFM should be considered in advanced heart failure patients. The SHFM may have utility as a virtual control arm for single-arm LVAD trials.
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Authors | Eric S Ketchum, Alec J Moorman, Daniel P Fishbein, Nahush A Mokadam, Edward D Verrier, Gabriel S Aldea, Shauna Andrus, Kenneth W Kenyon, Wayne C Levy |
Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 29
Issue 9
Pg. 1021-5
(Sep 2010)
ISSN: 1557-3117 [Electronic] United States |
PMID | 20558086
(Publication Type: Journal Article)
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Copyright | Copyright 2010 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Natriuretic Peptide, Brain
- Creatinine
|
Topics |
- Adult
- Aged
- Blood Urea Nitrogen
- Creatinine
(blood)
- Female
- Heart Failure
(mortality, surgery)
- Heart-Assist Devices
(statistics & numerical data)
- Humans
- Length of Stay
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Predictive Value of Tests
- Proportional Hazards Models
- Risk Assessment
- Stroke Volume
- Survival Rate
- Time Factors
- Washington
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