Abstract | BACKGROUND: MATERIALS AND METHODS: The methylation status of the TFPI2 gene was examined in primary carcinomas and corresponding normal tissues derived from 50 patients with colorectal cancer using quantitative methylation-specific PCR (qMSP), and the correlation between the methylation status and the clinicopathological findings was evaluated. Results. Methylation of the TFPI2 gene was detected in 31 out of the 50 (62%) primary colon carcinomas, suggesting that the methylation of TFPI2 is frequently observed in colorectal cancer. The clinicopathological data were compared with these results. Significant differences were observed between methylation of TFPI2 and histology (p=0.0053) or lymph node metastasis (p=0.0396). These results indicated that TFPI2 was more frequently methylated in well-differentiated advanced colorectal carcinomas. CONCLUSION:
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Authors | Kenji Hibi, Tetsuhiro Goto, Yo-Hei Kitamura, Kazuaki Yokomizo, Kazuma Sakuraba, Atsushi Shirahata, Hiroki Mizukami, Mitsuo Saito, Kazuyoshi Ishibashi, Gaku Kigawa, Hiroshi Nemoto, Yutaka Sanada |
Journal | Anticancer research
(Anticancer Res)
Vol. 30
Issue 4
Pg. 1205-7
(Apr 2010)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 20530429
(Publication Type: Journal Article)
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Chemical References |
- Glycoproteins
- tissue-factor-pathway inhibitor 2
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Topics |
- Aged
- Aged, 80 and over
- Cell Differentiation
(physiology)
- Colorectal Neoplasms
(genetics, pathology)
- DNA Methylation
- Female
- Glycoproteins
(genetics)
- Humans
- Male
- Middle Aged
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