[A case of breast cancer with extensive osteonecrosis of maxilla induced by a bisphosphonate].

Abstract

Here, we report a case of extensive osteonecrosis of the maxilla associated with a history of bisphosphonate (BP) therapy for management of bone metastases from breast cancer. A 66-year-old woman was referred to our hospital because of a fistulation on the right side of the maxilla in May 2005 by her dentist. The patient had a medical history of breast cancer with bone metastasis that was treated by chemotherapy with 45 mg pamidronate in 2 weekly courses for 16 months. We suspected that this rare case of osteonecrosis was caused by chemotherapy with BPs. Palliative treatments, including antibiotic therapy and local irrigation, were administered. Finally, extensive osteonecrosis of the maxilla occurred.

• Authors: Yoshihiro Tanaka, Makoto Koga, Yuji Yokomizo, Satoko Inokuchi, Chihiro Koga, Jingo Kusukawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 4 Pg. 681-5 (Apr 2010) ISSN: 0385-0684 [Print] Japan
• PMID: 20414026 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Diphosphonates
• Pamidronate

Topics

• Aged
• Antineoplastic Agents (adverse effects, therapeutic use)
• Bone Neoplasms (diagnostic imaging, drug therapy, secondary)
• Breast Neoplasms (drug therapy)
• Diphosphonates (adverse effects, therapeutic use)
• Female
• Humans
• Maxillary Diseases (chemically induced, diagnostic imaging, pathology, surgery)
• Osteonecrosis (chemically induced, diagnostic imaging, pathology, surgery)
• Palliative Care
• Pamidronate
• Tomography, X-Ray Computed