A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life.
Abstract | PURPOSE: This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies. METHODS: The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article. RESULTS: CONCLUSIONS: Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/ hematopoietic stem cell transplantation, and immunotherapy.
|
Authors | S B Jensen, A M L Pedersen, A Vissink, E Andersen, C G Brown, A N Davies, J Dutilh, J S Fulton, L Jankovic, N N F Lopes, A L S Mello, L V Muniz, C A Murdoch-Kinch, R G Nair, J J Napeñas, A Nogueira-Rodrigues, D Saunders, B Stirling, I von Bültzingslöwen, D S Weikel, L S Elting, F K L Spijkervet, M T Brennan, Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO) |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 18
Issue 8
Pg. 1039-60
(Aug 2010)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 20237805
(Publication Type: Journal Article, Review, Systematic Review)
|
Topics |
- Evidence-Based Emergency Medicine
- Humans
- Neoplasms
(therapy)
- Practice Guidelines as Topic
- Prevalence
- Quality of Life
- Salivary Gland Diseases
(epidemiology, etiology, physiopathology)
- Severity of Illness Index
- Xerostomia
(epidemiology, etiology, physiopathology)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|