Abstract |
Felbamate is a derivative of meprobamate used in second-line partial epilepsy and in the Lennox-Gastaut syndrome. Felbamate is well absorbed and has linear kinetics: C(max) and AUC increasing linearly with dose. The metabolism takes place in the liver. Metabolites represent 40 to 60% of excretion and are eliminated via the urine. The half-life is between 15 and 23 hours. Clearance is dependent on renal function. There is a concentration - efficacy and concentration - toxicity relationship. These arguments are in favour of a TDM but the therapeutic range is not clearly established. Potentially fatal side effects can be caused by felbamate ( aplastic anemia, acute liver failure), which limits its use because they are dose-independant.
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Authors | Olivier Tribut, Danièle Bentué-Ferrer, Marie-Clémence Verdier, le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique |
Journal | Therapie
(Therapie)
2010 Jan-Feb
Vol. 65
Issue 1
Pg. 35-8
ISSN: 0040-5957 [Print] France |
Vernacular Title | Suivi thérapeutique pharmacologique du felbamate. |
PMID | 20205993
(Publication Type: Journal Article, Review)
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Chemical References |
- Anticonvulsants
- Phenylcarbamates
- Propylene Glycols
- Felbamate
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Topics |
- Anticonvulsants
(administration & dosage, adverse effects, analysis, pharmacokinetics, therapeutic use)
- Drug Interactions
- Drug Monitoring
- Epilepsy
(drug therapy)
- Felbamate
- France
- Humans
- Phenylcarbamates
(administration & dosage, adverse effects, analysis, pharmacokinetics, therapeutic use)
- Propylene Glycols
(administration & dosage, adverse effects, analysis, pharmacokinetics, therapeutic use)
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