Abstract | OBJECTIVES: BACKGROUND: Without surgical correction, survival of patients with severe symptomatic aortic stenosis is poor. It is unknown whether patients undergoing transcatheter aortic valve implantation (TAVI) have a better prognosis than similar patients who are treated with medical management. METHODS: Survival rates were compared in consecutive patients with severe symptomatic aortic stenosis who either underwent TAVI or continued on medical management following multidisciplinary team assessment. All patients had been turned down, or considered at unacceptably high risk, for conventional aortic valve surgery. Patients were reviewed in clinic or by telephone six monthly. Mortality data was obtained from the United Kingdom Office of National Statistics. RESULTS: The study group included 85 patients aged 81 +/- 7 years (range 62-94), of whom 48 were male. Thirty eight patients underwent TAVI while 47 patients were deemed unsuitable based on echocardiographic, angiographic, or clinical criteria and remained on medical therapy. The calculated EuroSCORE for the TAVI group was 11 +/- 2 and for the medical group 9 +/- 2 (P < 0.001). TAVI-related procedural mortality was 2.6%, and 30-day mortality was 5.2%. Among the medically-treated patients, 14 (30%) underwent palliative balloon aortic valvuloplasty, with a trend toward improved survival (P = 0.06). During overall follow-up of 215 +/- 115 days there were a total of 18 deaths; TAVI N = 5 (13%); Medical N = 13 (28%) (P = 0.04). CONCLUSIONS:
|
Authors | Ronak Rajani, William Buxton, Peter Haworth, Muhammed Z Khawaja, Manav Sohal, Roberta L Brum, Nevil Hutchinson, Adam de Belder, Uday Trivedi, David Hildick-Smith |
Journal | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
(Catheter Cardiovasc Interv)
Vol. 75
Issue 7
Pg. 1121-6
(Jun 01 2010)
ISSN: 1522-726X [Electronic] United States |
PMID | 20146205
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
|
Topics |
- Aged
- Aged, 80 and over
- Aortic Valve Stenosis
(diagnosis, drug therapy, mortality, therapy)
- Cardiac Catheterization
(mortality)
- Cardiovascular Agents
(therapeutic use)
- Catheterization
(mortality)
- Chi-Square Distribution
- Female
- Heart Valve Prosthesis Implantation
(methods, mortality)
- Humans
- Kaplan-Meier Estimate
- Logistic Models
- Male
- Middle Aged
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Severity of Illness Index
- Time Factors
- Treatment Outcome
- United Kingdom
|