Pathogenesis of oxalate urolithiasis: lessons from experimental studies with rats.

Abstract	Calcium oxalate (CaOx) urolithiasis in rats is induced by producing hyperoxaluria. Depending on the degree and length of hyperoxaluria, CaOx crystals may either form in the nephron or the bladder and may or may not be retained in the kidneys. Crystals may nucleate in one part of the nephron and be retained in another part. Papillary collecting duct tubular epithelium and its basement membrane appear to be involved in crystal retention in the kidneys.
Authors	S R Khan
Journal	American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 17 Issue 4 Pg. 398-401 (Apr 1991) ISSN: 0272-6386 [Print] United States
PMID	2008907 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Calcium Oxalate
Topics	Animals Calcium Oxalate Crystallization Hyperoxaluria (complications, physiopathology) Kidney Calculi (chemistry, etiology, physiopathology, urine) Male Rats Rats, Inbred Strains

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