Ongoing remission after intensive ALL-type chemotherapy in pediatric intestinal T-cell lymphoma.

Abstract

A rare case of primary intestinal T-cell lymphoma (ITL) of an 8-year-old boy is reported. Medium- to large-sized tumor cells were betaF1+, CD3+, CD8+. TIA-1+, but CD4-, CD5-, CD30-, CD56-, CD20-, CD79a-, TdT-, consistent with an intraepithelial lymphocyte (IEL) origin. They showed monoclonal rearrangement of the T-cell receptor gamma-chain and no evidence of EBV infection. No clinical, histologic, laboratory, or genetic evidence of celiac disease was detected. In adults, ITL is often associated with enteropathy and has a very poor outcome. Our patient remains in first remission 30 months after finishing the acute lymphoblastic leukemia protocol COALL-07-03 high risk standard.

• Authors: Carsten Friedrich, Johanna Schrum, Andreas Chott, Gritta Janka-Schaub, Hartmut Kabisch
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 54 Issue 4 Pg. 610-2 (Apr 2010) ISSN: 1545-5017 [Electronic] United States
• PMID: 20049930 (Publication Type: Case Reports, Journal Article)

Chemical References

• Receptors, Antigen, T-Cell, gamma-delta
• Cytarabine
• Vincristine
• Etoposide
• Dexamethasone
• Doxorubicin
• Cyclophosphamide
• Mercaptopurine
• Thioguanine
• Methylprednisolone
• Methotrexate
• Daunorubicin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child
• Cyclophosphamide (administration & dosage)
• Cytarabine (administration & dosage)
• Daunorubicin (administration & dosage)
• Dexamethasone (administration & dosage)
• Doxorubicin (administration & dosage)
• Etoposide (administration & dosage)
• Humans
• Intestinal Neoplasms (drug therapy, genetics, pathology)
• Lymphoma, T-Cell (drug therapy, genetics, pathology)
• Male
• Mercaptopurine (administration & dosage)
• Methotrexate (administration & dosage)
• Methylprednisolone (administration & dosage)
• Neoplasm Staging
• Receptors, Antigen, T-Cell, gamma-delta (genetics)
• Remission Induction
• Thioguanine (administration & dosage)
• Vincristine (administration & dosage)