Synthesis and antitumor activities of phenanthrene-based alkaloids.

Abstract

A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 microM, respectively.

• Authors: Songtao Li, Li Han, Liang Sun, Dan Zheng, Jiang Liu, Yingbo Fu, Xueshi Huang, Zhanyou Wang
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 14 Issue 12 Pg. 5042-53 (Dec 07 2009) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 20032876 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents
• Phenanthrenes
• phenanthrene

Topics

• Alkaloids (chemical synthesis, chemistry, pharmacology)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Drug Screening Assays, Antitumor
• Magnetic Resonance Spectroscopy
• Phenanthrenes (chemistry)
• Spectrometry, Mass, Electrospray Ionization