Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.

Abstract	A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
Authors	Ehsan Samei, Robert S Saunders, Cristian T Badea, Ketan B Ghaghada, Laurence W Hedlund, Yi Qi, Hong Yuan, Rex C Bentley, Srinivasan Mukundan Jr
Journal	International journal of nanomedicine (Int J Nanomedicine) Vol. 4 Pg. 277-82 ( 2009) ISSN: 1178-2013 [Electronic] New Zealand
PMID	20011244 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Contrast Media Liposomes Iopamidol
Topics	Animals Cell Line, Tumor Contrast Media Female Iopamidol (chemistry) Liposomes (chemistry) Mammary Neoplasms, Animal (diagnostic imaging) Mammography (methods) Nanoparticles Radiographic Image Enhancement (methods) Rats Rats, Inbred F344 Tomography, X-Ray Computed (methods)

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