[A new combination therapy for diabetic gastroparesis].

Abstract

According to our knowledge and for the first time we refer about the combination therapy with gastric electric stimulation and injection of botulinus toxin into the pylorus at a patient with increased symptomatic diabetic gastroparesis for the first time. The prospectively documented gastroparesis-symptom-score improved dramatically under this combination therapy, while time of gastric emptying of 50 % (specified by scintigraphy) was showing solely a low decrease. 18 months after beginning the combination therapy its positive effect is to be watched furthermore, complications haven't occurred yet. The combination therapy with gastric electric stimulation and injection of botulinus toxin into the pylorus demonstrates one option of therapy-refractory diabetic gastroparesis, which has to be verified, however, in prospective studies in terms of its effectiveness.

• Authors: M Hummel, M Fuechtenbusch
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 47 Issue 12 Pg. 1216-20 (Dec 2009) ISSN: 1439-7803 [Electronic] Germany
• Vernacular Title: Neue Kombinationstherapie beidiabetischer Gastroparese.
• PMID: 19960400 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Botulinum Toxins, Type A (therapeutic use)
• Combined Modality Therapy (methods)
• Diabetes Mellitus, Type 1 (complications, therapy)
• Electric Stimulation Therapy (methods)
• Gastroparesis (etiology, therapy)
• Humans
• Male
• Middle Aged
• Neuromuscular Agents (therapeutic use)
• Treatment Outcome