Chemotherapy alone for organ preservation in advanced laryngeal cancer.

Abstract

BACKGROUND:

For patients with advanced laryngeal cancer, a trial was designed to determine if chemotherapy alone, in patients achieving a complete histologic complete response after a single neoadjuvant cycle, was an effective treatment with less morbidity than concurrent chemoradiotherapy.

METHODS:

Thirty-two patients with advanced laryngeal or hypopharyngeal cancer received 1 cycle of induction chemotherapy, and subsequent treatment was decided based on response.

RESULTS:

A histologic complete response was achieved in 4 patients and were treated with chemotherapy alone. All 4 patients' cancer relapsed in the neck and required surgery and postoperative radiotherapy (RT). Twenty-five patients were treated with concomitant chemoradiation. Three patients were treated with surgery. Overall survival and disease-specific survival at 3 years were 68% and 78%, respectively.

CONCLUSION:

Chemotherapy alone is not feasible for long-term control of regional disease in patients with advanced laryngeal cancer even when they achieve a histologic complete response at the primary site.

• Authors: Vasu Divi, Francis P Worden, Mark E Prince, Avraham Eisbruch, Julia S Lee, Carol R Bradford, Douglas B Chepeha, Theodoros N Teknos, Norman D Hogikyan, Jeffrey S Moyer, Christina I Tsien, Susan G Urba, Gregory T Wolf
• Journal: Head & neck (Head Neck) Vol. 32 Issue 8 Pg. 1040-7 (Aug 2010) ISSN: 1097-0347 [Electronic] United States
• PMID: 19953609 (Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, N.I.H., Extramural)
• Copyright: 2009 Wiley Periodicals, Inc. Head Neck, 2010.

Chemical References

• Antineoplastic Agents
• Carboplatin
• Cisplatin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Agents (therapeutic use)
• Carboplatin (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, pathology, surgery)
• Cisplatin (therapeutic use)
• Combined Modality Therapy
• Female
• Fluorouracil (therapeutic use)
• Follow-Up Studies
• Humans
• Hypopharyngeal Neoplasms (drug therapy, pathology, surgery)
• Laryngeal Neoplasms (drug therapy, pathology, surgery)
• Male
• Middle Aged
• Neoplasm Staging
• Treatment Outcome