Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-IT in two cases.

Abstract

Anti-IT is an unusual specificity originally described as a naturally occurring cold agglutinin. The antibody reacts strongly with cord RBCs, weakly with adult I RBCs, and most weakly with the rare adult i RBCs. IgG anti-IT in patients with hemolytic anemia has been associated with Hodgkin's lymphoma. Difficulties in blood grouping tests and the presence of a warm reactive agglutinin in samples from two patients with hemolytic anemia led to further serologic studies and the identification of anti-IT. In both cases, the anti-IT was a rarely encountered IgM warm reactive agglutinin; in one case, the IgG component was also anti-IT, whereas in the second case the IgG antibody was broadly reactive. The unusual serologic finding of anti-IT prompted further clinical evaluation for lymphoproliferative disease in these two patients.

• Authors: R M Leger, F Lowder, M C Dungo, W Chen, H M Mason, G Garratty
• Journal: Immunohematology (Immunohematology) Vol. 25 Issue 2 Pg. 60-2 ( 2009) ISSN: 0894-203X [Print] United States
• PMID: 19927621 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Autoantibodies
• I Blood-Group System
• Immunoglobulin M
• Immunoglobulins, Intravenous
• Rituximab
• Dexamethasone

Topics

• Anemia, Aplastic (blood, diagnosis, immunology, therapy)
• Anemia, Hemolytic, Autoimmune (blood, diagnosis, immunology, therapy)
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Murine-Derived
• Asian
• Autoantibodies (blood, immunology)
• Blood Transfusion
• Dexamethasone (therapeutic use)
• Erythrocyte Indices
• Female
• Hispanic or Latino
• Humans
• I Blood-Group System (immunology)
• Immunoglobulin M (blood)
• Immunoglobulins, Intravenous (therapeutic use)
• Male
• Pseudolymphoma (blood, diagnosis, immunology, therapy)
• Rituximab
• Tomography, X-Ray Computed
• Young Adult