Yttrium-90 radiotherapy for unresectable intrahepatic cholangiocarcinoma: a preliminary assessment of this novel treatment option.

Abstract

BACKGROUND:

There are no treatment options for unresectable intrahepatic cholangiocarcinoma (ICC) with proven efficacy. The objective of this study was to present data on the safety and efficacy of a novel treatment option, yttrium-90 ((90)Y) radioembolization for unresectable ICC.

METHODS:

Twenty-five patients underwent resin-based (90)Y radioembolization for unresectable ICC between January 2004 and May 2009. Patients were assessed at 1 month and then at 3-month intervals after treatment. Radiologic response was evaluated with the Response Criteria in Solid Tumors (RECIST) criteria. Clinical and biochemical toxicities were prospectively recorded. Survival was calculated by the Kaplan-Meier method and potential prognostic variables were identified.

RESULTS:

No patient was lost to follow-up. The median follow-up was 8.1 (range, 0.4-56) months and the median survival after (90)Y radioembolization was 9.3 months. Two patients died within 1 month of treatment; the median follow-up for the remaining 23 was 8.9 (range, 1.5-56) months. Two factors were associated with an improved survival: peripheral tumor type (vs. infiltrative, P = .004) and Eastern Cooperative Oncology Group performance status of 0 (vs. 1 and 2, P < .001). On imaging follow-up of 23 patients, a partial response to treatment was observed in 6 patients (24%), stable disease in 11 patients (48%), and progressive disease in 5 patients (20%). The most common clinical toxicities were fatigue (64%) and self-limiting abdominal pain (40%). Two patients (8%) each developed grade III bilirubin and albumin toxicity. One patient (4%) developed grade III alkaline phosphatase toxicity.

CONCLUSIONS:

(90)Y radioembolization may be a relatively safe and efficacious treatment for unresectable ICC. In the absence of other effective therapeutic options, this treatment warrants further investigation.

• Authors: Akshat Saxena, Lourens Bester, Terence C Chua, Francis C Chu, David L Morris
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 17 Issue 2 Pg. 484-91 (Feb 2010) ISSN: 1534-4681 [Electronic] United States
• PMID: 19876691 (Publication Type: Journal Article)

Chemical References

• Yttrium Radioisotopes

Topics

• Bile Duct Neoplasms (pathology, radiotherapy, surgery)
• Bile Ducts, Intrahepatic (radiation effects)
• Cholangiocarcinoma (pathology, radiotherapy, surgery)
• Embolization, Therapeutic
• Female
• Follow-Up Studies
• Humans
• Male
• Microspheres
• Middle Aged
• Prospective Studies
• Survival Rate
• Treatment Outcome
• Yttrium Radioisotopes (therapeutic use)