Immune response and viral persistence in Indian buffaloes (Bubalus bubalis) infected with foot-and-mouth disease virus serotype Asia 1.

Abstract

Despite their potential role in the spread of foot-and-mouth disease (FMD), the immune response and viral persistence in FMD virus (FMDV)-infected Indian buffaloes (Bubalus bubalis) have been unexplored. We found similar kinetics of neutralizing antibody responses in the sera and secretory fluids of buffaloes following experimental FMDV Asia 1 infection, but the lymphocyte-proliferative response in infected buffaloes was of low magnitude. Despite inducing a significant systemic and secretory immune response, viral persistence seems to be a common outcome in buffaloes following FMDV Asia 1 infection, which is associated with a weak cellular immune response.

• Authors: Mohan S Maddur, Subodh Kishore, S Gopalakrishna, Nem Singh, V V Suryanarayana, Mukund R Gajendragad
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 16 Issue 12 Pg. 1832-6 (Dec 2009) ISSN: 1556-679X [Electronic] United States
• PMID: 19828770 (Publication Type: Journal Article)

Chemical References

• Antibodies, Neutralizing
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M
• Mitogens
• Concanavalin A

Topics

• Animals
• Antibodies, Neutralizing (blood, immunology)
• Body Fluids (immunology, virology)
• Buffaloes (immunology, virology)
• Concanavalin A (pharmacology)
• Foot-and-Mouth Disease (immunology, virology)
• Foot-and-Mouth Disease Virus (immunology)
• Immunoglobulin A (blood)
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Leukocytes, Mononuclear (drug effects, immunology, virology)
• Mitogens (pharmacology)