Follicular dendritic cells in multicentric Castleman disease present human herpes virus type 8 (HHV8)-latent nuclear antigen 1 (LANA1) in a proportion of cases and is associated with an enhanced T-cell response.

Abstract

Multicentric Castleman disease (MCD) is a rare human herpes virus type 8 (HHV8)-associated lymphoproliferative disorder that occurs more frequently in patients infected with human immunodeficiency virus (HIV). In tissue samples, HHV8-infected plasmablasts localise to the mantle zones of the lymphoid follicles. We revisited the immunohistological features in 25 lymph node (LN) and three spleen samples of MCD. In five (20%) LN and one (33%) spleen sample, HHV8 latent nuclear antigen 1 (LANA1) staining was also noted on the follicular dendritic cells (FDC). The HHV8-positive FDC subgroup of patients had significantly higher numbers of CD3-positive T cells infiltrating the follicles when compared to the HHV8-negative FDC subgroup (P = 0.047). Furthermore, the numbers of HHV8-positive plasmablasts and serum HHV8 viral copy numbers were lower among the HHV8-positive FDC subgroup when compared to the HHV8-negative FDC subgroup (not statistically significant). Our findings show, for the first time, possible 'presentation' of an HHV8 antigen by FDCs in MCD.

• Authors: Hesham El-Daly, Mark Bower, Kikkeri N Naresh
• Journal: European journal of haematology (Eur J Haematol) Vol. 84 Issue 2 Pg. 133-6 (Feb 01 2010) ISSN: 1600-0609 [Electronic] England
• PMID: 19799625 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antigens, Viral
• CD3 Complex
• Nuclear Proteins
• latency-associated nuclear antigen

Topics

• Adult
• Aged
• Antigens, Viral (immunology, metabolism)
• CD3 Complex (immunology, metabolism)
• Castleman Disease (complications, immunology, metabolism, pathology, virology)
• Dendritic Cells (immunology, metabolism, pathology, virology)
• Female
• HIV (immunology, metabolism)
• HIV Infections (complications, immunology, metabolism, pathology, virology)
• Herpesviridae Infections (complications, immunology, metabolism, pathology, virology)
• Herpesvirus 8, Human (immunology, metabolism)
• Humans
• Lymph Nodes (immunology, metabolism, pathology, virology)
• Male
• Middle Aged
• Nuclear Proteins (immunology, metabolism)
• Spleen (immunology, metabolism, pathology, virology)
• T-Lymphocytes (immunology, metabolism, pathology, virology)