Paradoxical growth of Candida dubliniensis does not preclude in vivo response to echinocandin therapy.

Abstract

Candida dubliniensis commonly shows paradoxical or trailing growth effects in vitro in the presence of echinocandins. We tested the in vitro activities of anidulafungin, caspofungin, and micafungin against clinical isolates of C. dubliniensis and evaluated the efficacy of these drugs in two murine models of systemic infection. The three echinocandins were similarly effective in the treatment of experimental disseminated infections with C. dubliniensis strains showing or not showing abnormal growth in vitro.

• Authors: Marçal Mariné, F Javier Pastor, Ismail H Sahand, José Pontón, Guillermo Quindós, Josep Guarro
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 12 Pg. 5297-9 (Dec 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 19786599 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Echinocandins
• Lipopeptides
• Anidulafungin
• Caspofungin
• Micafungin

Topics

• Anidulafungin
• Animals
• Antifungal Agents (pharmacology, therapeutic use)
• Candida (drug effects, growth & development)
• Candidiasis (drug therapy, microbiology)
• Caspofungin
• Echinocandins (therapeutic use)
• Lipopeptides (therapeutic use)
• Male
• Micafungin
• Mice