Tolterodine causes measurable restoration of urethral sensation in women with urge urinary incontinence.

Abstract

UNLABELLED:

INTRODUCTION & HYPOTHESIS: Determine if treatment of urge incontinence with tolterodine results in changes in bladder and/or urethral sensation using Current Perception Threshold (CPT) testing.

METHODS:

Women with >or=1 incontinence episode on 7-day diary were treated with 4 mg of long-acting tolterodine for 2-months. At baseline and 2-months, participants had CPT testing of the urethral and bladder at 3 frequencies 2000, 250, and 5 Hz. Baseline and post-treatment measures were compared using Wilcoxon Signed Rank Test.

RESULTS:

Seventeen women underwent baseline CPT testing. Four discontinued medication due to side effects and did not have repeated testing. Urethral CPT at 250 Hz was lower after treatment (median 1.3 [Interquartile range .69-2.1] and .75 [.45-1.2], p = .003) and at 5 Hz trended toward a significant decrease (1.1 [1-1.9] and .84 [.32-1.1], p = .06).

CONCLUSIONS:

Urethral sensitivity improves after 2-months of tolterodine, suggesting it may restore urethral sensory nerves in addition to known motor effects.

• Authors: Kimberly Kenton, Lior Lowenstein, Linda Brubaker
• Journal: Neurourology and urodynamics (Neurourol Urodyn) Vol. 29 Issue 4 Pg. 555-7 (Apr 2010) ISSN: 1520-6777 [Electronic] United States
• PMID: 19771598 (Publication Type: Journal Article)
• Copyright: (c) 2009 Wiley-Liss, Inc.

Chemical References

• Benzhydryl Compounds
• Cresols
• Muscarinic Antagonists
• Phenylpropanolamine
• Tolterodine Tartrate

Topics

• Aged
• Benzhydryl Compounds (administration & dosage, adverse effects, therapeutic use)
• Cresols (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Middle Aged
• Muscarinic Antagonists (administration & dosage, adverse effects, therapeutic use)
• Phenylpropanolamine (administration & dosage, adverse effects, therapeutic use)
• Pilot Projects
• Proprioception (drug effects)
• Tolterodine Tartrate
• Treatment Outcome
• Urethra (drug effects, innervation, physiopathology)
• Urinary Bladder (drug effects, innervation, physiopathology)
• Urinary Incontinence, Urge (drug therapy, physiopathology)
• Urination