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Trisomy 8 in PDGFRB-negative cells in a patient with imatinib-sensitive chronic myelomonocytic leukemia and t(5;16)(q33;p13), PDGFRB-NDE1 fusion.

AuthorsFrancesco Cavazzini, Antonella Bardi, Maria Ciccone, Gian Matteo Rigolin, Paolo Gorello, Roberta La Starza, Cristina Mecucci, Antonio Cuneo
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 194 Issue 1 Pg. 67-9 (Oct 2009) ISSN: 1873-4456 [Electronic] United States
PMID19737658 (Publication Type: Case Reports, Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Benzamides
  • Microtubule-Associated Proteins
  • Nde1 protein, human
  • Oncogene Proteins, Fusion
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate
  • Receptor, Platelet-Derived Growth Factor beta
Topics
  • Antineoplastic Agents (therapeutic use)
  • Benzamides
  • Chromosomes, Human, Pair 16 (genetics)
  • Chromosomes, Human, Pair 5 (genetics)
  • Chromosomes, Human, Pair 8 (genetics)
  • Humans
  • Imatinib Mesylate
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myelomonocytic, Chronic (drug therapy, genetics, pathology)
  • Microtubule-Associated Proteins (genetics)
  • Oncogene Proteins, Fusion (genetics)
  • Piperazines (therapeutic use)
  • Pyrimidines (therapeutic use)
  • Receptor, Platelet-Derived Growth Factor beta (genetics)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Translocation, Genetic
  • Trisomy

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