Triplets with feto-fetal transfusion syndrome treated with laser ablation: the USFetus experience.

Abstract

OBJECTIVE:

We sought to assess outcomes of triplets with feto-fetal transfusion syndrome (FFTS) treated with selective laser photocoagulation of communicating vessels (SLPCV).

STUDY DESIGN:

All twins and triplets with FFTS treated with SLPCV were analyzed. Triplets were classified as dichorionic-triamniotic (D/T) or monochorionic-triamniotic (M/T). In M/T triplets, SLPCV between FFTS affected recipient-donor pairs was performed first (step 1); SLPCV of remaining vascular communications was then attempted (step 2).

RESULTS:

Forty-six of 692 (6.7%) gestations with FFTS treated with SLPCV were triplets; 40 (87%) were D/T, 6 (13%) were M/T. Overall perinatal survivorship in triplets versus twins were not different (73.9% vs. 75.1%, p = 0.757). SLPCV was achieved in 93% of D/T triplets. In the M/T triplets, step 1 was successful in all cases, and step 2 in half of cases. The D/T group delivered later in gestation than the M/T group (31.6 vs. 27.0 weeks, p = 0.049); no difference in overall perinatal survival was detected (75.8% vs. 61.1%, p = 0.248).

CONCLUSION:

Overall perinatal survival of triplets and twins with FFTS treated via SLPCV is similar. Significant surgical challenges were posed by monochorionic versus dichorionic triplets. Further studies of monochorionic triplets are required to ascertain perinatal survival post-SLPCV in this subset of triplets.

• Authors: Ramen H Chmait, Eftichia Kontopoulos, Patricia W Bornick, Terri Maitino, Rubén A Quintero
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 23 Issue 5 Pg. 361-5 (May 2010) ISSN: 1476-4954 [Electronic] England
• PMID: 19658042 (Publication Type: Evaluation Study, Journal Article, Multicenter Study)

Topics

• Female
• Fetal Therapies (methods, statistics & numerical data)
• Fetofetal Transfusion (surgery)
• Humans
• Laser Therapy (methods)
• Pregnancy
• Pregnancy, Multiple
• Retrospective Studies
• Syndrome
• Treatment Outcome
• Triplets
• Twins
• United States