Abstract |
Lymphoseek is a receptor-binding radiopharmaceutical specifically designed for sentinel lymph node (SLN) mapping. We conducted a clinical trial which measured the injection site clearance and sentinel lymph node accumulation after a single intradermal injection of Lymphoseek or unfiltered [(99m)Tc] sulfur colloid (TcSC) using a "2-day" protocol for SLN mapping of breast cancer. Eleven patients with breast cancer participated in this study. Five patients received an intradermal administration of 1.0 nmol of (99m)Tc-labeled Lymphoseek; SLN mapping was performed on four subjects within 19 to 27 h. Six subjects received an intradermal administration of TcSC; SLN mapping was performed on five subjects within 18 to 26 h. Lymphoseek exhibited a significantly (P<.001) faster injection site clearance than TcSC. The mean Lymphoseek clearance half-time was 2.18+/-1.09 h compared to 57.4+/-92.8 h for TcSC. The mean sentinel lymph node uptake of Lymphoseek (1.5+/-1.7%) and TcSC (3.5+/-3.1%) was statistically equivalent (P=.213). When an intradermal injection is employed, Lymphoseek demonstrated faster injection site clearance than unfiltered [(99m)Tc] sulfur colloid and persistent SLN accumulation for at least 24 h.
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Authors | Anne M Wallace, Carl K Hoh, Karl K Limmer, Denise D Darrah, Gery Schulteis, David R Vera |
Journal | Nuclear medicine and biology
(Nucl Med Biol)
Vol. 36
Issue 6
Pg. 687-92
(Aug 2009)
ISSN: 1872-9614 [Electronic] United States |
PMID | 19647175
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dextrans
- Mannans
- Organotechnetium Compounds
- Radiopharmaceuticals
- technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran
- Technetium Tc 99m Sulfur Colloid
- Pentetic Acid
- Technetium Tc 99m Pentetate
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Topics |
- Aged
- Breast Neoplasms
(metabolism, pathology)
- Dextrans
(administration & dosage, pharmacokinetics)
- Female
- Humans
- Injections, Intradermal
- Lymph Nodes
(metabolism)
- Mannans
(administration & dosage, pharmacokinetics)
- Middle Aged
- Organotechnetium Compounds
(administration & dosage, pharmacokinetics)
- Pentetic Acid
(administration & dosage, pharmacokinetics)
- Radioactivity
- Radiopharmaceuticals
(administration & dosage, pharmacokinetics)
- Sentinel Lymph Node Biopsy
- Technetium Tc 99m Pentetate
(analogs & derivatives)
- Technetium Tc 99m Sulfur Colloid
(administration & dosage, pharmacokinetics)
- Time Factors
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