Ipsilateral breast tumor relapse after breast conserving surgery in women with breast cancer.

Abstract

Ipsilateral breast tumor relapse (IBTR) is a potentially a significant problem after breast conserving surgery (BCS). With a median follow-up period of 64.7 months, IBTR occurred as a first relapse in 67 (3.0%) of a total of 2243 patients and distant recurrence occurred in 167 (7.4%). A positive surgical margin and the omission of radiotherapy (RT) were independently associated with IBTR. The five-year cumulative IBTR rates were 5.1% in patients with positive margins and 2.0% in the patients with negative margins. The five-year cumulative IBTR rates were 1.8% in patients with RT and 8.1% in patients without RT. IBTR was independently associated with distant-recurrence-free survival rates as well as age, nodal metastasis, lymphovascular invasion and progesterone receptor status. The five-year distant-recurrence-free survival rates were 81.9% in patients with IBTR and 93.2% in patients without IBTR. In order to prevent IBTR, a negative margin and the administration of RT are therefore considered to be important in patients who undergo BCS.

• Authors: Takashi Yoshida, Hiroyuki Takei, Masafumi Kurosumi, Jun Ninomiya, Yuko Ishikawa, Yuji Hayashi, Katsunori Tozuka, Hanako Oba, Kenichi Inoue, Toshio Tabei
• Journal: Breast (Edinburgh, Scotland) (Breast) Vol. 18 Issue 4 Pg. 238-43 (Aug 2009) ISSN: 1532-3080 [Electronic] Netherlands
• PMID: 19625190 (Publication Type: Journal Article)

Topics

• Adult
• Breast Neoplasms (mortality, pathology, radiotherapy, surgery)
• Disease-Free Survival
• Female
• Humans
• Lymphatic Metastasis
• Mastectomy, Segmental
• Multivariate Analysis
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (epidemiology)
• Radiotherapy, Adjuvant
• Risk Factors