Abstract |
Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimer's disease and as antitumour agents.
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Authors | A A Weekes, A D Westwell |
Journal | Current medicinal chemistry
(Curr Med Chem)
Vol. 16
Issue 19
Pg. 2430-40
( 2009)
ISSN: 1875-533X [Electronic] United Arab Emirates |
PMID | 19601790
(Publication Type: Journal Article, Review)
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Chemical References |
- Amyloid
- Antineoplastic Agents
- Benzothiazoles
- Contrast Media
|
Topics |
- Alzheimer Disease
(diagnosis)
- Amyloid
(metabolism)
- Antineoplastic Agents
(chemistry, pharmacology)
- Benzothiazoles
(chemistry, pharmacology)
- Contrast Media
(chemistry)
- Drug Design
- Humans
- Neoplasms
(drug therapy)
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