HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

2-Arylbenzothiazole as a privileged scaffold in drug discovery.

Abstract
Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimer's disease and as antitumour agents.
AuthorsA A Weekes, A D Westwell
JournalCurrent medicinal chemistry (Curr Med Chem) Vol. 16 Issue 19 Pg. 2430-40 ( 2009) ISSN: 1875-533X [Electronic] United Arab Emirates
PMID19601790 (Publication Type: Journal Article, Review)
Chemical References
  • Amyloid
  • Antineoplastic Agents
  • Benzothiazoles
  • Contrast Media
Topics
  • Alzheimer Disease (diagnosis)
  • Amyloid (metabolism)
  • Antineoplastic Agents (chemistry, pharmacology)
  • Benzothiazoles (chemistry, pharmacology)
  • Contrast Media (chemistry)
  • Drug Design
  • Humans
  • Neoplasms (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: