Therapeutic efficacy of a composition of amphotericin B and dialdehyde dextran in kidney damage in mice of various strains with systemic candidiasis.

Abstract	The therapeutic efficacy of a composition of amphotericin B and dialdehyde dextran was much higher than that of amphotericin B in the therapy for systemic candidiasis. This conclusion was derived from the earlier and progressive decrease in the number and size of candidal granulomas in the kidneys. The composition of amphotericin B and dialdehyde dextran was more potent than amphotericin B in decreasing the nephrotoxic effect of C. albicans. The opposite strains of CBA and C57Bl/6 mice differed in morphological signs of granulomatosis in the kidneys, but not in the nephrotoxic effect of C. albicans metabolites.
Authors	A A Pristavka, A P Nadeev, M A Travin, V A Shkurupiy
Journal	Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 146 Issue 6 Pg. 826-8 (Dec 2008) ISSN: 1573-8221 [Electronic] United States
PMID	19513396 (Publication Type: Journal Article)
Chemical References	Anticoagulants Antifungal Agents Dextrans dextran dialdehyde Amphotericin B
Topics	Amphotericin B (pharmacology, therapeutic use) Animals Anticoagulants (pharmacology, therapeutic use) Antifungal Agents (pharmacology, therapeutic use) Candidiasis (drug therapy) Dextrans (pharmacology, therapeutic use) Kidney (drug effects) Kidney Diseases (drug therapy, microbiology, pathology) Male Mice Mice, Inbred C57BL Mice, Inbred CBA

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