Breast cancer associated with type 1 neurofibromatosis.

Abstract

The association between breast cancer and type 1 neurofibromatosis (NF1) is a rare clinical entity. We herein present the case of a 59-year-old woman, with typical clinical manifestations of NF1, who presented with a painless lump in her right breast, which she had first noticed 8 months earlier. Clinical examination and diagnostic workup were suggestive of a breast carcinoma, and a modified radical mastectomy was performed. Histopathological examination revealed a poorly differentiated invasive ductal breast carcinoma and multiple neurofibromas. The pathological staging was pT2N1a according to TNM/UICC. Delayed presentation of the patient was the result of her mistakenly identifying the breast tumor as a manifestation of NF1 neurofibromatosis.

• Authors: Nikolaos S Salemis, Georgios Nakos, Dimitrios Sambaziotis, Stavros Gourgiotis
• Journal: Breast cancer (Tokyo, Japan) (Breast Cancer) Vol. 17 Issue 4 Pg. 306-9 (Oct 2010) ISSN: 1880-4233 [Electronic] Japan
• PMID: 19466510 (Publication Type: Case Reports, Journal Article)

Topics

• Breast Neoplasms (complications, diagnosis)
• Carcinoma, Ductal, Breast (complications, diagnosis)
• Female
• Humans
• Middle Aged
• Neurofibromatosis 1 (complications)