Abstract | BACKGROUND: OBJECTIVE: METHODS: This 8-week, randomized, investigator-blind study, compared the once-daily, two-compound scalp formulation ( calcipotriol 50 microg/g plus betamethasone 0.5 mg/g as dipropionate; Xamiol, LEO Pharma A/S, Ballerup, Denmark) with twice-daily calcipotriol scalp solution (50 microg/mL; Daivonex, LEO Pharma A/S) in patients with scalp psoriasis of at least moderate severity covering > or = 10% of the scalp. QoL was assessed (weeks 0, 2, 4, 8) using the 36-item Short Form Health Survey (version 2; SF-36v2) and Skindex-16. RESULTS: Treatment with the two-compound scalp formulation (n = 207) resulted in significant improvements from baseline on the SF-36v2 (Physical Component Summary, P = 0.005, week 8; Mental Component Summary, P < 0.05, weeks 2, 4, 8). A significant change from baseline in the calcipotriol scalp solution group (n = 105) was seen only on the Mental Component Summary (P = 0.04, week 8). Change from baseline in Skindex-16 was significantly in favour of the two-compound scalp formulation. Change was significant on both total score and individual scales. CONCLUSION:
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Authors | J P Ortonne, C Ganslandt, J Tan, P Nordin, K Kragballe, S Segaert |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 23
Issue 8
Pg. 919-26
(Aug 2009)
ISSN: 1468-3083 [Electronic] England |
PMID | 19453810
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Dermatologic Agents
- calcipotriene
- Betamethasone
- Calcitriol
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents
(therapeutic use)
- Betamethasone
(therapeutic use)
- Calcitriol
(analogs & derivatives, therapeutic use)
- Chemistry, Pharmaceutical
- Dermatologic Agents
(therapeutic use)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Psoriasis
(drug therapy, psychology)
- Psychology
- Quality of Life
(psychology)
- Scalp Dermatoses
(drug therapy, psychology)
- Single-Blind Method
- Treatment Outcome
- Young Adult
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