Vasoplegic syndrome during liver transplantation.

Abstract

A 56-yr-old woman with chronic hepatitis B and decompensated hepatic cirrhosis was treated with liver transplantation. At the beginning of the neohepatic phase, her arterial blood pressure remained at 60/40 mm Hg for approximately 40 min and did not respond to vasoconstrictive drugs. Her other clinical and laboratory values remained normal, apart from a high cardiac output and low systemic vascular resistance. This patient was diagnosed with vasoplegic syndrome and was treated with i.v. infusion of methylene blue (0.5 mg/kg) and norepinephrine. This report has potential significance to treatment in patients who undergo orthotopic liver transplantation.

• Authors: Zhongping Cao, Yuqi Gao, Guocai Tao
• Journal: Anesthesia and analgesia (Anesth Analg) Vol. 108 Issue 6 Pg. 1941-3 (Jun 2009) ISSN: 1526-7598 [Electronic] United States
• PMID: 19448226 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antidotes
• Vasoconstrictor Agents
• Phenylephrine
• Methylene Blue
• Norepinephrine

Topics

• Adult
• Antidotes (therapeutic use)
• Blood Gas Analysis
• Cardiac Output, High (drug therapy, physiopathology)
• Female
• Hemodynamics (drug effects)
• Hepatitis B (surgery)
• Humans
• Hypotension (drug therapy, physiopathology)
• Intraoperative Complications (drug therapy, physiopathology)
• Liver Cirrhosis (surgery)
• Liver Transplantation (physiology)
• Methylene Blue (therapeutic use)
• Norepinephrine (therapeutic use)
• Phenylephrine (therapeutic use)
• Syndrome
• Tachycardia (drug therapy, physiopathology)
• Vascular Resistance (drug effects, physiology)
• Vasoconstrictor Agents (therapeutic use)
• Water-Electrolyte Balance (drug effects, physiology)