Increased CD4+CD25+Foxp3+ T cells in peripheral blood of celiac disease patients: correlation with dietary treatment.

Abstract

Regulatory CD4+ CD25+Foxp3+ T cells are involved in the regulation of immune response and inhibit protective antitumor immunity. Celiac disease (CD), a food gluten-sensitive enteropathy, is considered a T-cell-mediated autoimmune disease and is generally associated with an overall increased risk of cancer in CD patients. We observed a higher percentage of circulating CD4+CD25+Foxp3+ T cells and an increased Foxp3 expression in CD4+CD25+ T cells from untreated than from treated CD patients. In co-culture, CD4+CD25+ T cells from both treated and untreated CD patients significantly suppressed the proliferation of autologous CD4+CD25(-) T cells similarly to values in healthy subjects. Our study suggests that Treg proportion and Foxp3 expression in circulating CD4+CD25+ T cells could justify the increased global risk of malignancy in CD population and support the efficacy of lifelong gluten-free diet in the reduction of the cancer risk.

• Authors: Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Bianco Assunta, Domenico Plantone, Giovanni Cammarota, Pietro Attilio Tonali, Anna Paola Batocchi
• Journal: Human immunology (Hum Immunol) Vol. 70 Issue 6 Pg. 430-5 (Jun 2009) ISSN: 1879-1166 [Electronic] United States
• PMID: 19364517 (Publication Type: Journal Article)

Chemical References

• CD4 Antigens
• FOXP3 protein, human
• Forkhead Transcription Factors
• Interleukin-2 Receptor alpha Subunit

Topics

• Adolescent
• Adult
• CD4 Antigens (blood, immunology)
• CD4-Positive T-Lymphocytes (immunology, pathology)
• Celiac Disease (diet therapy, immunology, pathology)
• Cell Proliferation
• Cells, Cultured
• Diet, Gluten-Free
• Female
• Forkhead Transcription Factors (blood, immunology)
• Humans
• Interleukin-2 Receptor alpha Subunit (blood, immunology)
• Longitudinal Studies
• Male
• Middle Aged
• T-Lymphocytes (immunology, pathology)
• T-Lymphocytes, Regulatory (immunology, pathology)
• Young Adult