[Histomorphology of angiogenesis patterns in different areas of human astrocytomas].

Abstract

OBJECTIVE:

To study angiogenesis patterns in the edematous area and the center of human astrocytomas by histological observation, and to reveal histological basis of vasculogenic mimicry.

METHOD:

Tissue samples were drawn from the tumor center and the edematous area in 51 patients with human astrocytomas during operation MR and were examined by CD34 endothelial marker periodic acid-Schiff (PAS) dual staining.

RESULTS:

Vessels or capillaries stained by both PAS and CD34 were found in edematous areas of human astrocytomas. Besides vessels or capillaries stained by both PAS and CD34, vasculogenic mimicries (PAS-positive and CD34-negative tubes containing red blood cells and lined by neoplastic cells), PAS-positive and CD34-negative tubes containing red blood cells and without cells around, PAS-positive and partial CD34-positive vessels or capillaries, and PAS-positive and CD34-negtive vessels or capillaries were detected in the center of tumor of 4 human glioblastomas.

CONCLUSIONS:

Vasculogenic mimicries in the center of some high-grade astrocytomas may be caused by blood capillary dysplasia, while angiogenesis patterns are vessels or capillaries in the edematus area and the center of most human astrocytomas.

• Authors: Hao Wang, Song-tao Qi, Zhi-wang Guo, Ke-wan Wang, Xiao-jun Liu, Guo-zhong Zhang
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 29 Issue 2 Pg. 326-9 (Feb 2009) ISSN: 1673-4254 [Print] China
• PMID: 19246314 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, CD34

Topics

• Adolescent
• Adult
• Aged
• Antigens, CD34 (analysis)
• Astrocytoma (blood supply, pathology)
• Brain (pathology)
• Brain Edema (etiology, pathology)
• Brain Neoplasms (blood supply, pathology)
• Child
• Female
• Humans
• Male
• Middle Aged
• Neovascularization, Pathologic (pathology)
• Young Adult