[A case of simultaneous double cancers with multiple liver metastases responding to S-1+CPT-11].

Abstract

The patient was a 70-year-old male with advanced cancers of stomach and rectum and multiple metastatic hepatic tumors. No resectability was detected. The origin of metastatic hepatic tumors was unknown, so the combination of S- / 1 and CPT-11 as a treatment regimen was selected. S-1, 80 mg m(2), was administered on 14 consecutive days followed / by a 14-day rest period, and CPT-11, 100 mg/m(2), was administered on day 1 and day 15. One cycle was defined as 4 weeks, and cycles were repeated. CR was achieved as long as metastatic hepatic tumors after completion of 5 cycles. When we encounter a case of simultaneous double cancers with metastatic sites which has no respectability, generally speaking, it is difficult to determine the strategy for chemotherapy. This case suggests that the combination of S-1 and CPT-11 may be an effective regimen for the treatment of simultaneous advanced cancers of stomach and rectum with multiple hepatic metastases.

• Authors: Toshiro Iizuka, Naoki Hirano, Daisuke Kikuchi, Shu Hoteya, Naohisa Yahagi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 1 Pg. 139-41 (Jan 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19151581 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carcinoembryonic Antigen
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Irinotecan
• Camptothecin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biopsy
• Camptothecin (analogs & derivatives, therapeutic use)
• Carcinoembryonic Antigen (blood)
• Drug Combinations
• Endoscopy, Gastrointestinal
• Humans
• Irinotecan
• Liver Neoplasms (blood, diagnostic imaging, drug therapy, secondary)
• Male
• Neoplasms, Multiple Primary (blood, drug therapy, pathology)
• Oxonic Acid (therapeutic use)
• Rectal Neoplasms (blood, drug therapy, pathology, surgery)
• Stomach Neoplasms (blood, drug therapy, pathology, surgery)
• Tegafur (therapeutic use)
• Tomography, X-Ray Computed
• Treatment Outcome