A feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation for malignant pleural mesothelioma.

Abstract

A prospective multi-institutional study has been commenced in Japan to evaluate the feasibility of induction chemotherapy using pemetrexed plus cisplatin, followed by extrapleural pneumonectomy (EPP) and postoperative hemithoracic radiation in patients with resectable malignant pleural mesothelioma. The study was initiated on May 2008 and 40 patients will be recruited over 3 years. Primary endpoints are macroscopic complete resection rate by EPP and treatment-related mortality for trimodality therapy. Secondary endpoints include treatment completion rate, adverse events, response rate by chemotherapy and 2-year overall and relapse-free survival.

• Authors: Takeharu Yamanaka, Fumihiro Tanaka, Seiki Hasegawa, Morihito Okada, Toshinori Soejima, Norihiko Kamikonya, Kazuya Fukuoka, Takashi Nakano
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 39 Issue 3 Pg. 186-8 (Mar 2009) ISSN: 1465-3621 [Electronic] England
• PMID: 19131427 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Glutamates
• Pemetrexed
• Guanine
• Cisplatin

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Bayes Theorem
• Chemotherapy, Adjuvant (adverse effects)
• Cisplatin (administration & dosage)
• Endpoint Determination
• Feasibility Studies
• Female
• Glutamates (administration & dosage)
• Guanine (administration & dosage, analogs & derivatives)
• Humans
• Japan
• Male
• Mesothelioma (drug therapy, radiotherapy, surgery, therapy)
• Middle Aged
• Neoadjuvant Therapy (methods)
• Patient Selection
• Pemetrexed
• Pleural Neoplasms (drug therapy, radiotherapy, surgery, therapy)
• Pneumonectomy (methods)
• Radiotherapy, Adjuvant (adverse effects)
• Remission Induction
• Research Design
• Sample Size