[Expressions of HLA class I antigen and CD8 and their clinical significance in cervical cancer].

Abstract

OBJECTIVE:

To examine the expressions of HLA class I antigen and CD8 in various cervical diseases and investigate their association with cervical cancer.

METHODS:

The expressions of HLA class I antigen and CD8 in cervical tissues sampled from patients with cervical cancer, cervical intraepithelial neoplasia (CIN), and chronic cervicitis were detected using SP immunohistochemistry. The association of the expressions of HLA class I antigen and CD8 with the clinicopathologic indices of the patients was analyzed.

RESULTS:

The positive expression rates of HLA class I antigen in cervical cancer, CIN, and chronic cervicitis were 22.6%, 100.0%, and 100.0%, and the positive expression rates of CD8 were 22.6%, 95.5%, and 100.0%, respectively. The positive rates of HLA class I antigen and CD8 were significantly lower in patients with cervical cancer (P<0.01). Patients with stage I cervical cancer had significantly higher positive rates of HLA class I antigen and CD8 than those with stage II cervical cancer (46.7% vs 0.0%, 46.7% vs 0.0%, both P<0.01). The expressions of HLA class I antigen and CD8 decreased with the progression of the clinicopathological stages, and may even become undetectable. The expressions of HLA class I antigen and CD8 were not related to the differentiation degree of the tumor or lymph node metastasis (P>0.05). A positive correlation was found between HLA class I antigen expression and CD8 expression.

CONCLUSION:

The expressions of HLA class I antigen and CD8 are down-regulated or deleted in CIN and cervical cancer, and they may play important roles in the development and progression of CIN and cervical cancer.

• Authors: Yue Qi, Jin-Shuang Huang, Dong-dong Wang, Fan Zhang, Shu-lan Zhang
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 28 Issue 12 Pg. 2165-9 (Dec 2008) ISSN: 1673-4254 [Print] China
• PMID: 19114347 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CD8 Antigens
• Histocompatibility Antigens Class I

Topics

• Adult
• Aged
• CD8 Antigens (immunology, metabolism)
• Down-Regulation
• Female
• Histocompatibility Antigens Class I (immunology, metabolism)
• Humans
• Middle Aged
• Uterine Cervical Neoplasms (immunology, pathology)
• Uterine Cervical Dysplasia (immunology, pathology)