Abstract | PURPOSE: To characterize longitudinal tumor progression in a murine orthotopic model of liver metastasis using susceptibility contrast magnetic resonance imaging (MRI). MATERIALS AND METHODS: RESULTS: All intrasplenically inoculated mice developed liver metastases, evident in both T(2)- and T(2)-weighted images as high-signal deposits, compared to feruglose-nulled normal liver. Small lesions were detected as early as day 10 and all mice exhibited progressing lesions over 35 days. Liver metastases took longer to establish, but exhibited a similar volume doubling time to the subcutaneously propagated tumors of approximately 2-3 days. Different functional tumor vascular architectures between the two growth sites were apparent. CONCLUSION: Susceptibility-contrast MRI using a single dose of feruglose can be used to easily detect and longitudinally monitor orthotopically propagated liver metastases in vivo.
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Authors | Tammy L Kalber, John C Waterton, John R Griffiths, Anderson J Ryan, Simon P Robinson |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
Vol. 28
Issue 6
Pg. 1451-8
(Dec 2008)
ISSN: 1053-1807 [Print] United States |
PMID | 19025954
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2008 Wiley-Liss, Inc. |
Chemical References |
- Benzimidazoles
- Dextrans
- Magnetite Nanoparticles
- Oxides
- Iron
- ferumoxides
- bisbenzimide ethoxide trihydrochloride
- Ferrosoferric Oxide
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Topics |
- Animals
- Benzimidazoles
- Colorectal Neoplasms
(pathology)
- Dextrans
- Disease Progression
- Ferrosoferric Oxide
- Hypoxia
- Image Enhancement
(methods)
- Image Processing, Computer-Assisted
- Iron
- Liver Neoplasms, Experimental
(blood supply, secondary)
- Magnetic Resonance Imaging
(methods)
- Magnetite Nanoparticles
- Mice
- Mice, Nude
- Necrosis
- Neoplasm Transplantation
- Oxides
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